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Oregon was inhabited by many indigenous tribes before Western traders, explorers, and settlers arrived. An autonomous government was formed in the Oregon Country in 1843 before the Oregon Territory was created in 1848. Oregon became the 33rd state on February 14, 1859. Today, at 98,000 square miles (250,000 km2), Oregon is the ninth largest and, with a population of 4 million, 27th most populous U.S. state. The capital, Salem, is the second most populous city in Oregon, with 164,549 residents. Portland, with 632,309 residents, is the most populous and ranks as the 26th most populous city in the United States. The Portland metropolitan area, which also includes the city of Vancouver, Washington, to the north, ranks the 23rd largest metro area in the nation, with a population of 2,389,228.
Humans have inhabited the land now known as Missouri for at least 12,000 years. The Mississippian culture built cities and mounds, before declining in the 1300s. When European explorers arrived in the 1600s they encountered the Osage and Missouria nations. The French established Louisiana, a part of New France, and founded Ste. Genevieve in 1735 and St. Louis in 1764. After a brief period of Spanish rule, the United States acquired the Louisiana Purchase in 1803. Americans from the Upland South, including enslaved African Americans, rushed into the new Missouri Territory. Many from Virginia, Kentucky, and Tennessee settled in the Boonslick area of Mid-Missouri. Soon after, heavy German immigration formed the Missouri Rhineland.